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¿ø¹®:
You might think Peter Duesberg would have learned his lesson. In 1987
the University of California virologist declared that recreational and
other drugs, not the HIV virus, cause AIDS. He even offered to inject
himself with the virus to prove it. The radical theory "didn't help my
career," Duesberg acknowledges today. Grants dried up. Graduate
students steered clear of his lab.
 
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copyright ¨Ï Hankooki.com All rights reserved. 

 --------------------
Popular Science 
Once shunned for his AIDS theories, Peter Duesberg is back in the
spotlight.

by Michael Stroh April 2004

You might think Peter Duesberg would have learned his lesson. In 1987
the University of California virologist declared that recreational and
other drugs, not the HIV virus, cause AIDS. He even offered to inject
himself with the virus to prove it. The radical theory "didn't help my
career," Duesberg acknowledges today. Grants dried up. Graduate
students steered clear of his lab.

But none of this has stopped Duesberg from challenging mainstream
theories. Now he's taking aim at one of cancer research's most dearly
held hypotheses: that deadly tumors arise when a handful of genes go
bad.

In January, Duesberg organized a scientific conference in Berkeley to
debate an alternative theory. It's not faulty genes that cause cancer, he
argues, but faulty chromosomes. If he's right, his ideas could
fundamentally change how doctors screen for cancer, and could lead to
earlier tumor detection.

A normal human cell contains 46 chromosomes. Most tumor cells
contain double or triple that; in some, chromosomes are also missing or
mangled. The condition, called aneuploidy, was first linked to cancer in
1914 but the connection was eventually pushed aside when scientists
(Duesberg among them) discovered oncogenes-- genes that spur tumor
growth. If a few oncogenes mutate, the theory goes, uncontrolled cell
division, or cancer, will follow. But, Duesberg argues, the disease
doesn't always follow. Scientists have genetically engineered rodents
teeming with oncogenes and yet these animals, he notes, rarely become
tumorous. "If the mutation theory was right," he says, "those mice
should be meatballs." Moreover, cells within the same tumor don't
always manifest the same mutated genes.

To explain these apparent gaps in cancer's central dogma, Duesberg
has put forth this theory: A carcinogen--say, tobacco smoke--causes a
cell to produce daughter cells with malformed chromosomes. Since a
single chromosome can host thousands of genes, the reshuffling that
occurs during replication creates widespread chemical mayhem. Years or
decades later, the process yields a cell with a deadly combination of
mutant genes.

While Duesberg's concept of cancer is far less radical than his AIDS
theory, which he still believes, many researchers remain skeptical.
Aneuploidy, they contend, is little more than a side effect of cancer.
Robert Weinberg, a breast cancer researcher at the Whitehead Institute
in Massachusetts, says his lab has created tumor cells with a normal
set of chromosomes. "He has chosen to ignore that data," Weinberg
says.

But even if Duesberg's theory proves rubbish, some scientists say he's
helping to stimulate new thinking about cancer's origins. "Just because
he had some weird ideas about AIDS at one point, it doesn't mean he's
an idiot," says Johns Hopkins cancer researcher Christoph Lengauer.
"He's helped the discussion."

Copyright ¨Ï 2004 Popular Science. A Time4 Media Company. All rights
reserved. 
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